Covered topics - NAFLD pathogenesis, patient management, prognostic and
therapeutic targets, non-invasive assessment of fibrosis, apoptosis,
biomarkers, insulin resistance and signalling, hormonal and bile acids
signalling, oxidative and mitochondrial stress, inflammation and
immunity in NASH, carcinogenesis, gut microbiota.
We would like to cordially invite you to the First EASL Nonalcoholic Fatty Liver Disease (NAFLD) Summit: Target-oriented approach to Diagnosis and Pharmacotherapy of Nonalcoholic Steatohepatitis (NASH), a dialogue between Academia and Industryâ to be held on the 9 to 11 November 2017 in Rome, Italy.
NAFLD is the leading cause of chronic liver disease not only in Western countries but also among developing countries of the Far East, South Asia, the Middle East, and Latin America. In the US and Europe, nearly 40% of the population have NAFLD and approximately 20% of these individuals are likely to develop progressive liver disease (i.e. NASH) that leads to liver fibrosis and cirrhosis. Another emerging challenge is hepatocellular cancer, which increasingly arises in precirrhotic stages. Although a significant number of new drugs are already in the development pipeline, none are as yet, approved by regulatory agencies. As such, the identification and development of new therapies is urgently needed.
This summit will cover both the basic and translational / clinical aspects of NAFLD, with a specific focus on novel drug target and prognostic signature development.
Key sessions include all crucial pathophysiological aspects currently known to affect development and progression of NAFLD, such as "lipid metabolism and lipotoxicity" and "insulin resistance, insulin and hormonal signaling". Furthermore, oxidative stress, ER stress, and mitochondrial dysfunction will be addressed. On the second day, inflammation, adaptive and innate immunity as well as apoptosis and microparticles will be discussed in the NAFLD context. Moreover, bile acids and bile acid signaling as well as gut microbiota will be covered. Finally, key aspects of hepatic fibrosis and carcinogenesis in relation to NAFLD will be addressed.Unlike other NAFLD meetings, this inaugural summit will feature a significant representation by industry partners and presentations will be delivered by both academia and industry leaders to stimulate our joint efforts in addressing the key challenges across the spectrum of NAFLD.